Nano-analytics in Pharmaceutics
: Aden Hodzic
CERIC-ERIC offers services based on Nano-analytical and multi-technique methodologies, which will be applied in the project in order to meet the requirements imposed on modern pharmaceutical products, as well as to satisfy new restrictive quality rules. The research team will use Nano-analytical multi-techniques for the development of drug formulations and release in solid, liquid-crystal (lipid nanoparticles formulation) and liquid state (oral dosage form formulation). The examples are systems enclosed with active pharmaceutical ingredients (APIs). Drug release and quantification of the samples is very time-consuming and cost-intensive. Therefore, the PI proposes to work on a methodology based on Nano analytics, which may overcome this problem by serving and predicting dissolution and structural properties in the time range of minutes. The research will impact the therapeutic performance of Nano-systems once administered. So far, only a small number of analytical tools are available. Hence, the research project focuses on the application and development of new Nano-methodologies for developing the drugs of tomorrow.
Scientific field(s) and main challenges of the project
The increasing importance of Nano analytics for pharmaceutical technology opens a new field of applications for drug research and quality control by using, applying and developing novel tools. The upcoming (European, national and international) laws and regulations for ensuring quality of products will bring more rigorous rules especially in the pharmaceutical and food industries. Hence, the development/application of new methods that allow useful results in the more sensible Nano-range, may respond to the new requirements and lead to a better quality of development and production as well as to shorter production-times, while avoiding drug side effects and bringing a financial benefit.
Resources and Laboratories
- XRD Beamline (Italian CERIC partner facility at Elettra Sincrotrone Trieste), Italy